When I first read Scott's post on it, I decided to give ISAPI_Rewrite a try.  I've been thinking for a while to re-direct the end-point of my blog from

http://lozanotek.com

http://www.lozanotek.com

to

http://blog.lozanotek.com

Why?  Well, I've always been a fan of subdomains that define a purpose rather than the typical /InsertYourAppNameHere.  Technically they're the same, but it's just nice to "package" your web application under it's own subdomain.  I mean, come'on, you spent the time working it, why shouldn't it have it's own spot?  Remember, when you buy a domain name, you buy *.mydomainnamehere.com not just the www subdomain.

I agree with everyone that has used ISAPI_Rewrite, it's pretty easy to setup and deploy.  The regexs for the redirection of the requests are actually not that bad.  My httpd.ini is about 4 lines long and things are just up and running fine.  This ISAPI filter is a great product!